Sildenafil citrate is the active ingredient in Viagra and many generic versions. It’s a phosphodiesterase-5 (PDE5) inhibitor. This means it works by increasing blood flow to the penis.
How Sildenafil Citrate Affects the Body
Specifically, sildenafil blocks the PDE5 enzyme. This enzyme normally breaks down cyclic GMP, a molecule that relaxes the muscles in the blood vessels of the penis. By inhibiting PDE5, sildenafil allows cyclic GMP to persist, leading to vasodilation (widening of blood vessels) and increased blood flow. This facilitates an erection in response to sexual stimulation.
Important Considerations
Sildenafil requires sexual stimulation to work; it doesn’t cause erections spontaneously. It’s crucial to consult a doctor before using sildenafil, especially if you have heart problems, high or low blood pressure, or other health conditions. Potential side effects include headache, flushing, nasal congestion, and upset stomach. Always follow your doctor’s prescribed dosage.
Dosage and Administration
Typical starting doses range from 25 to 50 milligrams. Your doctor will determine the appropriate dose based on your individual needs and health status. It’s usually taken orally about an hour before sexual activity. Avoid grapefruit juice, as it can affect sildenafil’s metabolism.
