Potential Interactions with Other Medications and Substances

Disulfiram (Antabuse) interacts significantly with several medications and substances. Always inform your doctor and pharmacist of all medications, supplements, and substances you consume, including alcohol, before starting Antabuse.

Combining Antabuse with alcohol causes a severe adverse reaction, including nausea, vomiting, flushing, and rapid heartbeat. This reaction can be dangerous, even life-threatening.

Certain medications increase the risk of adverse effects when taken with Antabuse. These include metronidazole, isoniazid, and some antidepressants. Your doctor might adjust dosages or suggest alternatives.

Warfarin and other anticoagulants can interact with Antabuse, increasing bleeding risk. Close monitoring of blood clotting is crucial.

Some medications metabolized by the liver, such as phenytoin, may experience altered levels when combined with Antabuse, requiring dose adjustments.

Avoid consuming products containing alcohol, such as cough syrups or mouthwashes, while taking Antabuse. Even small amounts can trigger a reaction.

Always consult your healthcare provider before taking Antabuse with other medications or substances. They can provide personalized guidance and ensure your safety.