Always inform your doctor about all medications you’re taking, including over-the-counter drugs, supplements, and herbal remedies, before starting Viagra. Some medications can significantly affect how Viagra works or increase the risk of side effects.
Medications That Can Increase Viagra’s Side Effects
- Nitrates: Combining Viagra with nitrates (found in medications for chest pain) can cause a dangerous drop in blood pressure. This combination is strictly contraindicated. Alpha-blockers: These medications, often prescribed for high blood pressure or enlarged prostate, can also lower blood pressure, increasing the risk of dizziness or fainting when taken with Viagra. CYP3A4 Inhibitors: Certain medications, like some antifungals (ketoconazole, itraconazole) and HIV protease inhibitors (ritonavir, indinavir), inhibit the enzyme that breaks down Viagra, leading to higher Viagra levels in your blood and an increased risk of side effects.
Medications That Can Decrease Viagra’s Effectiveness
- CYP3A4 Inducers: Medications like rifampin (an antibiotic) and St. John’s Wort (an herbal supplement) can speed up Viagra’s breakdown, reducing its effectiveness.
Other Important Considerations
Discuss potential interactions with your doctor: This list is not exhaustive. Your doctor can provide a personalized assessment of potential interactions based on your specific medical history and medications. Avoid grapefruit juice: Grapefruit juice contains compounds that can interact with Viagra, potentially increasing its levels in your blood. Regularly review your medications: Any changes to your medication regimen should be discussed with your physician to ensure continued safety and efficacy of Viagra.
Specific Examples of Interactions (Consult your physician for a complete list)
This section provides a few examples, but is not exhaustive. Always refer to your physician for complete and current information.
- Amlodipine (Norvasc): An interaction with Viagra is possible, warranting careful monitoring by your doctor. Cimetidine (Tagamet): This can potentially increase Viagra blood levels.


