Always inform your doctor about all medications and supplements you’re taking, including over-the-counter drugs and herbal remedies, before starting metformin. This prevents potentially harmful interactions.
Medications
- Alcohol: Combining metformin with alcohol increases the risk of lactic acidosis, a serious condition. Avoid alcohol consumption while on metformin. ACE inhibitors and ARBs: These blood pressure medications may increase the risk of kidney problems when combined with metformin. Your doctor will monitor your kidney function closely. Diuretics: Some diuretics can deplete your body of fluids, potentially increasing the risk of metformin-related side effects. Close monitoring is necessary. NSAIDs (Nonsteroidal anti-inflammatory drugs): Using NSAIDs like ibuprofen or naproxen with metformin may increase the risk of kidney damage. Your doctor might suggest alternative pain relievers. Certain antibiotics: Some antibiotics can affect how your body processes metformin. Your doctor may adjust your metformin dose or switch to a different antibiotic.
Supplements
B vitamins: Some evidence suggests B vitamins may interfere with metformin absorption. Consult your doctor if you take high doses of B vitamins. Niacin: High doses of niacin can raise blood sugar levels, potentially reducing metformin’s effectiveness. Discuss this with your physician. St. John’s Wort: This herbal supplement can interact with metformin, potentially reducing its effectiveness. Avoid using it alongside metformin.
This list isn’t exhaustive. Many other medications and supplements can interact with metformin. Open communication with your healthcare provider is paramount for safe and effective metformin use. Regular check-ups are crucial for monitoring your health while taking this medication.


