Always inform your doctor about all medications you are taking before starting Cialis, including over-the-counter drugs and supplements. Certain combinations can lead to dangerous interactions.
Nitrates
Cialis interacts dangerously with nitrates, often found in medications for chest pain (angina). This combination can cause a significant drop in blood pressure, leading to dizziness, fainting, or even a heart attack. Avoid using Cialis if you take nitrates.
Alpha-blockers
Alpha-blockers, used to treat high blood pressure and prostate problems, can also interact with Cialis. This combination may significantly lower blood pressure, potentially causing dizziness or fainting. Your doctor may adjust your dosages or recommend an alternative treatment.
CYP3A4 Inhibitors
- Ketoconazole Itraconazole Erythromycin Clarithromycin Grapefruit juice
These medications and grapefruit juice inhibit the enzyme CYP3A4, which processes Cialis. This can lead to increased Cialis levels in your blood, increasing the risk of side effects. Discuss alternative medications with your doctor if you are taking any of these.
Other Medications
Guanylate cyclase stimulators: Such as riociguat, used to treat pulmonary hypertension. Combining this with Cialis can cause a dangerous drop in blood pressure. Certain HIV medications: Some protease inhibitors can interact with Cialis, requiring dosage adjustments.
Consult Your Doctor
This list isn’t exhaustive. Always consult your physician or pharmacist before taking Cialis with any other medication, including herbal remedies or supplements. They can assess your specific health conditions and medication interactions, ensuring safe and effective treatment.


