Drug Interactions: What to Avoid When Combining Viagra and Cialis

Never combine Viagra and Cialis. Taking both simultaneously significantly increases the risk of dangerously low blood pressure and heart problems. This combination overwhelms your body’s ability to regulate blood flow, leading to potentially serious consequences.

Specific Medications to Avoid

Beyond the obvious simultaneous use, combining either Viagra or Cialis with nitrates (found in some heart medications) is extremely risky. Nitrates and PDE5 inhibitors like Viagra and Cialis both lower blood pressure, and this interaction can cause a dramatic drop, leading to fainting or even heart attack. Avoid alpha-blockers (used to treat high blood pressure and prostate issues) as well, as this combination can also cause dangerously low blood pressure. Consult your doctor before combining either drug with any other medication, particularly those for heart conditions or high blood pressure.

Grapefruit juice interacts negatively with both Viagra and Cialis, inhibiting the body’s ability to break down the medications. This results in higher-than-normal drug levels in the bloodstream, greatly increasing the chance of side effects. Avoid grapefruit and grapefruit juice completely when using these medications.