Avanafil’s metabolism involves the CYP3A4 enzyme. Therefore, co-administration with strong CYP3A4 inhibitors, such as ketoconazole, ritonavir, or clarithromycin, may significantly increase Avanafil blood levels, potentially leading to increased side effects. Consult your doctor before combining Avanafil with these medications.
Conversely, strong CYP3A4 inducers like rifampin can decrease Avanafil levels, potentially reducing its effectiveness. Open communication with your physician is crucial if you’re taking rifampin or similar drugs.
Alpha-blockers, frequently prescribed for hypertension or benign prostatic hyperplasia, can cause additive hypotensive effects when combined with Avanafil. This may result in dizziness or fainting, particularly upon standing. Your doctor should carefully monitor your blood pressure.
Nitrates, used to treat angina, should be avoided completely. The combination with Avanafil poses a serious risk of dangerously low blood pressure. This interaction is potentially life-threatening.
While this information covers common interactions, this list is not exhaustive. Always inform your doctor or pharmacist about all medications, including over-the-counter drugs, supplements, and herbal remedies, you are taking before starting Avanafil. This allows them to assess potential risks and adjust your treatment plan accordingly.
