Always inform your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies, before starting hydrochlorothiazide. This helps prevent potentially harmful interactions.
Lithium
Hydrochlorothiazide can increase lithium levels in your blood, leading to lithium toxicity. Your doctor will need to monitor your lithium levels closely if you’re taking both medications.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Using NSAIDs like ibuprofen or naproxen with hydrochlorothiazide can reduce the effectiveness of hydrochlorothiazide in lowering blood pressure and may increase the risk of kidney problems. Discuss alternative pain management options with your physician.
Digoxin
Hydrochlorothiazide can increase the risk of digoxin toxicity. Your doctor should regularly monitor your digoxin levels if you’re taking both medications.
Diabetes Medications
Hydrochlorothiazide may increase blood sugar levels, potentially affecting the effectiveness of your diabetes medications. Close monitoring of your blood sugar is crucial. Your doctor may adjust your diabetes medication dosage accordingly.
Other Medications
Hydrochlorothiazide can interact with various other medications, including but not limited to: certain antihypertensive drugs, cholestyramine, and medications affecting potassium levels. Always provide a complete list of your medications to your doctor or pharmacist.
Potential Side Effects from Interactions
| Lithium | Nausea, vomiting, diarrhea, tremors, confusion |
| NSAIDs | Reduced blood pressure control, kidney problems |
| Digoxin | Heart rhythm problems, nausea, vomiting |
| Diabetes Medications | Increased blood sugar levels |
This information is not exhaustive. Consult your healthcare provider for personalized advice regarding potential drug interactions with hydrochlorothiazide.
