Viagra, or sildenafil, primarily targets a specific enzyme called phosphodiesterase-5 (PDE5). PDE5 breaks down cyclic GMP, a molecule crucial for achieving and maintaining an erection. By inhibiting PDE5, Viagra allows cyclic GMP levels to rise.
Increased Cyclic GMP: The Key to Erection
Higher cyclic GMP levels trigger a series of events. Specifically, it leads to increased blood flow into the penis by relaxing the smooth muscles in the blood vessel walls. This increased blood flow fills the erectile tissues, resulting in an erection.
Understanding the Process Step-by-Step:
Sexual stimulation triggers the release of nitric oxide (NO). NO activates an enzyme called guanylate cyclase. Guanylate cyclase produces cyclic GMP. Cyclic GMP relaxes smooth muscles in the penis. Relaxed muscles allow increased blood flow into the penis. Viagra prevents the breakdown of cyclic GMP, prolonging the effects of NO and maintaining the erection.
Factors Affecting Viagra’s Action:
- Proper sexual stimulation is necessary. Viagra doesn’t spontaneously create erections. Individual responses vary due to factors like age, overall health, and pre-existing conditions. Certain medications can interact with Viagra, so always consult a doctor before use.
Remember to consult your physician before using Viagra or any other medication for erectile dysfunction.
