Zetia contains ezetimibe, a medication that lowers cholesterol. It works differently than statins, targeting cholesterol absorption in your intestines. Specifically, ezetimibe blocks the absorption of cholesterol from your diet and bile, reducing the amount entering your bloodstream.
How Ezetimibe Works
Ezetimibe selectively inhibits the Niemann-Pick C1-like 1 (NPC1L1) protein. This protein is found in the cells lining your small intestine and plays a key role in cholesterol absorption. By blocking NPC1L1, ezetimibe prevents cholesterol from being absorbed, thus lowering your LDL (“bad”) cholesterol levels.
Zetia vs. Statins
| Mechanism of Action | Inhibits cholesterol absorption | Inhibits cholesterol production in the liver |
| Primary Target | Intestinal cholesterol absorption | Liver cholesterol synthesis |
| Common Side Effects | Generally well-tolerated; mild diarrhea, muscle aches are possible. | Muscle aches (myalgia), elevated liver enzymes are more common. |
Consult your doctor to determine the best cholesterol-lowering strategy for you. They can assess your individual needs and health status to recommend the most appropriate medication or combination of medications.
Important Considerations
While Zetia is generally safe, potential side effects exist. Always inform your doctor about all medications you’re taking, including over-the-counter drugs and supplements, to avoid interactions. Regular monitoring of cholesterol levels is crucial when using Zetia.
