Understanding Viagra’s Mechanism of Action

Viagra, or sildenafil, works by inhibiting an enzyme called phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for achieving and maintaining an erection.

Increased cGMP Levels

By blocking PDE5, Viagra allows cGMP levels to rise. Higher cGMP levels relax the smooth muscles in the penis, increasing blood flow. This increased blood flow is what causes an erection.

The Role of Nitric Oxide

The process begins with the release of nitric oxide (NO) during sexual stimulation. NO triggers the production of cGMP, starting the chain reaction. Viagra enhances this effect by preventing cGMP breakdown.

Important Considerations:

Factor Effect
Sexual Stimulation Necessary to initiate the NO release and the erection process; Viagra alone won’t cause an erection.
Dosage Dosage affects the duration and intensity of the effect. Consult a doctor for appropriate dosage.
Health Conditions Pre-existing heart conditions, low blood pressure, or other health issues may interact with Viagra. Discuss any health concerns with your doctor.

Potential Side Effects:

Common side effects include headache, facial flushing, and nasal congestion. More serious side effects are rare but require immediate medical attention. Always consult a doctor before using Viagra.