Hydrochlorothiazide can interact with numerous medications, altering their effects or your body’s response. Always inform your doctor about all medications, supplements, and herbal remedies you’re taking, including over-the-counter drugs. This allows your doctor to assess potential risks and adjust your treatment plan accordingly.
Medications that May Interact Significantly
Lithium: Hydrochlorothiazide can increase lithium levels in your blood, potentially leading to lithium toxicity. Regular monitoring of your lithium levels is vital if you’re taking both medications. Digoxin: Hydrochlorothiazide can also increase digoxin levels, potentially causing heart rhythm problems. Your doctor should closely monitor your heart rate and rhythm. Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs like ibuprofen or naproxen can reduce the blood pressure-lowering effect of hydrochlorothiazide. Diabetes medications: Hydrochlorothiazide may increase blood sugar levels, potentially requiring adjustments to your diabetes medication dosage.
Other Potential Interactions
Alcohol: Combining alcohol with hydrochlorothiazide can increase the risk of low blood pressure and dizziness. Certain antibiotics: Some antibiotics may interact with hydrochlorothiazide, potentially affecting their effectiveness or increasing side effects. Potassium supplements: Hydrochlorothiazide can lower potassium levels; therefore, taking potassium supplements requires careful monitoring to avoid hyperkalemia. Antihypertensives: Using hydrochlorothiazide alongside other blood pressure medications can lead to excessive blood pressure lowering. Your doctor will carefully manage your medications to prevent this. Always discuss potential drug interactions with your physician or pharmacist before starting or changing any medications.
