Always inform your doctor about all medications you take, including over-the-counter drugs, herbal supplements, and recreational drugs. Sildenafil can interact negatively with certain substances, potentially leading to dangerous side effects. This includes nitrates, often prescribed for chest pain (angina). Combining these can cause a drastic drop in blood pressure, potentially leading to fainting or a heart attack.
Nitrates and Sildenafil: A Dangerous Combination
Nitrates and sildenafil are incompatible. Never combine them. This includes medications like nitroglycerin, isosorbide mononitrate, and isosorbide dinitrate. If you are prescribed nitrates, discuss alternative erectile dysfunction treatments with your doctor.
Other Medications and Interactions
Sildenafil can also interact with other medications, including:
| Alpha-blockers (for high blood pressure) | Increased risk of low blood pressure |
| CYP3A4 inhibitors (like ketoconazole and erythromycin) | Increased sildenafil levels in the blood |
| CYP3A4 inducers (like rifampin and St. John’s Wort) | Decreased sildenafil levels in the blood |
| Blood thinners (like warfarin) | Increased risk of bleeding |
Alcohol and Sildenafil
While moderate alcohol consumption usually doesn’t cause major issues, excessive alcohol use can worsen sildenafil’s side effects, such as dizziness and headache. Limit alcohol intake when using sildenafil.
Grapefruit Juice
Grapefruit juice contains compounds that inhibit the enzymes responsible for sildenafil breakdown. This can increase sildenafil levels in your blood, intensifying both its effects and side effects. Avoid grapefruit juice while taking sildenafil.
Always Consult Your Doctor
This information isn’t exhaustive, and individual reactions can vary. Before taking sildenafil, or if you experience any unexpected effects, consult your physician immediately. They can provide personalized advice based on your health history and current medications.
